The game develops a setting common to the entire Uncharted series. Game played from a third-person perspective, with the player in control of Nathan "Nate" Drake. This is a person passionately carried away by historical riddles, promising a reward in the form of hidden treasures.
Drake can run with acceleration, make jumps, swim, climb up. Sometimes he demonstrates something completely acrobatic. For confrontation with opponents, he uses the art of hand-to-hand combat with a variety of attacks, including a battle with several opponents simultaneously. He also has a surprise concerning dealing with firearms. Weapons and ammunition he picks up from the defeated opponents.
From time to time, further movement in the game requires the hero to find solutions to puzzles, using his diary and the hints of the game itself.
Nathan with his mentor Victor Sullivan travels in search of the lost city. List of locations includes the streets of London, cities and deserts on the Middle East, a château in France etc.